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US 8,785,442 B2Granted
Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof
AssigneeCuregenix, Inc.
InventorsSongzhu An, Chufang Li, Guisheng Zhou, Chen Huang
Life of this patent
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Abstract
The present invention relates to a compound as antagonist of LPA receptor, and a pharmaceutical composition comprising the same. The present invention also relates to the use of the compound and the composition, and a method of using the compound to treat, prevent or diagnose diseases, disorders or conditions associated with one or more of the LPA receptors.
Claims9
A compound of Formula (I):
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein,
- when R4 is H, R1 is C(═O)R5 or SO2R5;
- or
- R4 and NHR1, together with the two C atoms of the phenyl ring to which R4 and NHR1 are respectively attached, form a fused saturated, partially saturated or unsaturated 5-7 membered heterocycle which optionally contains 1-2 heteroatoms selected from N, O or S in addition to the N atom shown;
- each R2 and R3 is independently selected from H, F, Cl, Br, CN, OH, or C1-C4alkyl;
- R5 is C1-C6 alkyl, C1-C6 aryl, C1-C6 alkoxyl, C3-6 cycloalkyl, 5 or 6 membered heteroaryl containing 1-2 heteroatoms selected from N, O or S;
- 5-6 membered heterocyclyl containing 1-2 heteroatoms selected from N, O or S, wherein C1-C6 alkyl, C1-C6 aryl, C1-C6 alkoxyl, C3-6 cycloalkyl, 5 or 6 membered heteroaryl and 5-6 membered heterocyclyl are optionally substituted with F, Cl, Br, I, —CN, —C(═O)—OH, —C(═O)—O—C1-6 alkyl, —S(═O)2—C1-6 alkyl;
- each m and n is 0, 1 or 2.
5 more elements
Dependencies are inferred from the claim text.