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US 8,785,435 B2Granted
Solid forms
AssigneeHoffmann-La Roche Inc.
InventorsPascal Dott, Olaf Grassmann, Michael Kammerer, Joachim Manns, Urs Schwitter, Andrew Thomas, Nicole Wyttenbach
Life of this patent
Estimating the term…
Abstract
The instant invention relates to novel solid forms of the compound of formula (I) as well as solvates, inclusion complexes with other suitable compounds, processes for their manufacture, pharmaceutical compositions containing these solid forms, and their use as pharmaceuticals.
Claims8
A solid font of the compound of formula (I)
- having an XRPD pattern comprising at least one XRPD peak in the range of angles of diffraction 2Theta of 10.3° to 13.3°, wherein the solid form is crystalline (1,1-dioxo-1λ6-thiomorpholin-4-yl)-{6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-methanone in anhydrous polymorphic form C.
A high-shear process for preparing a solid form of a compound of formula (I)
- having an XRPD pattern comprising at least one XRPD peak in the range of angles of diffraction 2Theta of 103° to 13.3° comprising:
- a) injecting a solution of an educt solid form of compound (I) in a solvent into a high-shear mixer having a rotor-stator system comprising an antisolvent;
- b) agitating the rotor-stator system of the high-shear mixer to form a suspension;
- and
- c) physically separating the solid form from the suspension.
2 more elements
A pharmaceutical composition comprising a solid form of a compound of formula (I) the compound of formula (I)
- having an XRPD pattern comprising at least one XRPD peak in the range of angles of diffraction 2Theta of 103° to 13.3°
- and a pharmaceutically acceptable excipient,
- wherein the solid form is crystalline (1,1-dioxo-1λ6-thiomorpholin-4-yl)-{6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-methanone in anhydrous polymorphic form C,
- wherein the pharmaceutical composition is administered in an administrative form selected from tablets, powders, and capsules.
1 more element
Dependencies are inferred from the claim text.