Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases

A method of causing an effect in a prostate cancer cell, wherein the effect is selected from the group consisting of inducing cell cycle arrest in a cell, inducing growth arrest in a cell and inducing apoptosis in a cell, the method comprising coadministering, sequentially or coextensively, to the prostate cancer cell of a patient in need thereof an effective dose of a combination of an amount of a compound of Formula II and

• and an amount of thapsigargin, wherein coadministration of the amount of the compound and the amount of thapsigargin to the cell causes said effect in the cell.