Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsRamachandran Murali, Mark I. Greene
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Abstract
Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.
Claims5
A method of inhibiting CD4-mediated signaling in a subject comprising administering to said subject an effective amount of a compound of Formula (IV), (V), or (VI),
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound having the
- or a pharmaceutically acceptable salt thereof, and a pharmaceutical acceptable carrier or diluent.
Dependencies are inferred from the claim text.