Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases
AssigneesThe Texas A&M University System, Temple Therapeutics, Inc.
InventorsDarwin J. Prockop, Joo Youn Oh, Gavin W. Roddy, Robert Rosa, Barry A. Berkowitz
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Abstract
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties. The invention includes administration of TSG-6, STC-1, or a combination thereof to the ocular as a treatment for an ocular disease, disorder or condition in a mammal.
Claims6
A method of treating an injury to the cornea in a patient, comprising:
- administering to said patient a therapeutic agent for treating an injury to the cornea consisting of TSG-6 protein or a biologically active fragment, or variant thereof, wherein said TSG-6 protein or biologically active fragment, or variant thereof is administered in an amount effective to treat said injury to the cornea in said patient.
A method of treating an injury to the cornea in a patient, comprising:
- administering to the cornea of said patient eye drops containing a therapeutic agent for treating an injury to the cornea consisting of TSG-6 protein or a biologically active fragment, or variant thereof, and wherein said TSG-6 protein or biologically active fragment, variant, or analog thereof is contained in said eye drops in an amount effective to treat said injury to the cornea in said patient.
Dependencies are inferred from the claim text.