US 8,785,388 B2 · TAT-BH3 methods for treating arthritis

Abstract

The present invention is directed to compositions and methods for treating immune system mediated disease. In particular, certain embodiments of the present invention use BH3 mimetic therapy as an efficacious treatment of the effector phase of RA wherein the compositions and methods of the present invention markedly reduce the level of the Bcl-2 antagonist protein Bim present in RA synovial tissue as compared to control patients. Therefore, the present invention involves restoring the function of Bim in order to ameliorate inflammatory arthritis. In connection therewith, systemic delivery of a peptide to the BH3 domain of Bim effectively inhibits the development of K/B×N serum transfer-induced arthritis which closely resembles the effector phase of RA.

Claims9

Dependent claims

A method of treating an immune-mediated disease in a patient comprising the step of:

administering a pharmaceutical composition to said patient in need thereof, said composition including a cell delivery agent that is a cell-penetrating peptide selected from the group consisting of TAT, penetratin, VP22, transportan, synthetic oligoarginines, and combinations thereof that is conjugated to a cell death agent that is the BH3 domain of Bim, in an amount sufficient to provide a clinically observable improvement in the disease symptoms of said patient;
wherein said immune-mediated disease is selected from the group consisting of rheumatoid arthritis and juvenile polyarticular rheumatoid arthritis.

Dependencies are inferred from the claim text.

Facts

Application

12/031,118Filed 14 Feb 2008 · us provisional application

Priority

14 Feb 2007

Published

US 2008/0234178 A125 Sep 2008

Granted

22 Jul 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 38/1709
From vertebrates: from mammals
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61P 37/02
Drugs for immunological or allergic disorders: immunomodulators
Y02A 50/30
In human health protection, e.g. against extreme weather: against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne…

TAT-BH3 methods for treating arthritis

Life of this patent

TAT-BH3 methods for treating arthritis

Life of this patent

Abstract

Claims9