Peptide synthesis
AssigneeChemical & Biopharmaceutical Laboratories of Patras S.A.
InventorKleomenis K. Barlos
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Abstract
A process for producing an insulin type peptide, for example a relaxin, involving oxidizing a methionine residue on a B-chain having cysteine residues and combining the B chain with an A chain having cysteine residues to form a peptide having intermolecular disulphide links and biological activity. Novel synthetic relaxin 1 and methionine oxidized relaxins and Met(O) B-chains having enhanced solubility are disclosed.
Claims10
A synthetically produced, isolated human relaxin 1 and a pharmaceutically acceptable salt, wherein the relaxin 1 contains one methionine sulphoxide residue wherein the methionine sulphoxide is a Met(O)24-RLX1B or Met(O)25 relaxin 1.
A biologically active, synthetic relaxin containing one methionine sulphoxide residues and a pharmaceutically acceptable salt, wherein the methionine sulphoxide is a Met(O)24-RLX1B or Met(O)25 relaxin 1.
An isolated synthetic polypeptide comprising a polypeptide sequence of a synthetic relaxin A-chain, a synthetic relaxin B-chain comprising a single methionine oxide analogue.
Dependencies are inferred from the claim text.