Tetrazolyl macrocyclic hepatitis C serine protease inhibitors

A compound represented by Formula I, II, III or IV:

• or a pharmaceutically acceptable salt thereof, wherein
• A is selected from the group consisting of R1, —(C═O)—O—R1, —(C═O)—R2, —C(═O)—NH—R2, —S(O)2—R1, and —S(O)2NHR2;
• R1 is selected from the group consisting of:
• (i) aryl;
• substituted aryl;
• heteroaryl;
• substituted heteroaryl;
• (ii) heterocycloalkyl or substituted heterocycloalkyl;
• and
• (iii) —C1-C8 alkyl, —C2-C8 alkenyl, or —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N;
• substituted —C1-C8 alkyl, substituted —C2-C8 alkenyl, or substituted —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;
• —C3-C12 cycloalkyl, or substituted —C3-C12 cycloalkyl;
• —C3-C12 cycloalkenyl, or substituted —C3-C12 cycloalkenyl;
• R2 is independently selected from the group consisting of:
• (i) hydrogen;
• (ii) aryl;
• substituted aryl;
• heteroaryl;
• substituted heteroaryl;
• (iii) heterocycloalkyl or substituted heterocycloalkyl;
• and
• (iv) —C1-C8 alkyl, —C2-C8 alkenyl, or —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N;
• substituted —C1-C8 alkyl, substituted —C2-C8 alkenyl, or substituted —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;
• —C3-C12 cycloalkyl, or substituted —C3-C12 cycloalkyl;
• —C3-C12 cycloalkenyl, or substituted —C3-C12 cycloalkenyl;
• G is selected from the group consisting of —NHS(O)2—R3 and —NH(SO2)NR4R5;
• R3 is selected from the group consisting of:
• (i) heteroaryl;
• substituted heteroaryl;
• and
• (ii) heterocycloalkyl or substituted heterocycloalkyl;
• R4 and R5 are independently selected from:
• (i) hydrogen;
• (ii) aryl;
• substituted aryl;
• heteroaryl;
• substituted heteroaryl;
• (iii) heterocycloalkyl or substituted heterocycloalkyl;
• and
• (iv) —C1-C8 alkyl, —C2-C8 alkenyl, or —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N;
• substituted —C1-C8 alkyl, substituted —C2-C8 alkenyl, or substituted —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;
• —C3-C12 cycloalkyl, or substituted —C3-C12 cycloalkyl;
• —C3-C12 cycloalkenyl, or substituted —C3-C12 cycloalkenyl;
• L is selected from the group consisting of —CH2—, —O—, —S—, and —S(O)2—;
• X is selected from the group consisting of:
• (i) hydrogen;
• (ii) aryl;
• substituted aryl;
• heteroaryl;
• substituted heteroaryl;
• (iii) heterocycloalkyl or substituted heterocycloalkyl;
• (iv) —C1-C8 alkyl, —C2-C8 alkenyl, or —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N;
• substituted —C1-C8 alkyl, substituted —C2-C8 alkenyl, or substituted —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;
• —C3-C12 cycloalkyl, or substituted —C3-C12 cycloalkyl;
• —C3-C12 cycloalkenyl, or substituted —C3-C12 cycloalkenyl;
• and
• (v) —W—R6, where W is absent, or selected from —O—, —S—, —NH—, —N(Me)—, —C(O)NH—, and —C(O)N(Me)-;
• R6 is selected from the group consisting of:
• (a) hydrogen;
• (b) aryl;
• substituted aryl;
• heteroaryl;
• substituted heteroaryl
• (c) heterocyclic or substituted heterocyclic;
• and
• (d) —C1-C8 alkyl, —C2-C8 alkenyl, or —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;
• substituted —C1-C8 alkyl, substituted —C2-C8 alkenyl, or substituted —C2-C8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;
• —C3-C12 cycloalkyl, or substituted —C3-C12 cycloalkyl;
• —C3-C12 cycloalkenyl, or substituted —C3-C12 cycloalkenyl;
• denotes a carbon-carbon single or double bond
• j=0, 1, 2, 3, or 4;
• k=1, 2, or 3;
• m=0, 1, or 2;
• and
• n=1, 2 or 3.