Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration
AssigneeMorehouse School of Medicine
InventorByron D. Ford
Life of this patent
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Abstract
Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.
Claims20
A method for ameliorating occlusive stroke damage in a patient by increasing migration of neural stem cells to damaged areas of the brain, comprising the step of:
- administering an effective neural stem cell migration-inducing and inflammation inhibiting amount of neuregulin-1 to a patient who has suffered an occlusive stroke, wherein said neuregulin-1 is administered within about 13.5 to 72 hours after the onset of said occlusive stroke.
A method for ameliorating occlusive stroke damage in a patient, comprising:
- administering an effective amount of neuregulin-1 to a patient who has suffered an occlusive stroke, wherein said neuregulin-1 is administered within about 13.5 to 72 hours after the onset of said occlusive stroke.
Dependencies are inferred from the claim text.