Prebiotic formulations and methods of use
AssigneeRitter Pharmaceuticals, Inc.
InventorsAndrew J. Ritter, Dennis Savaiano, David Barnes, Todd Klaenhammer
Life of this patent
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Abstract
The invention provides methods and pharmaceutical compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and pharmaceutical compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a pharmaceutical composition comprising a prebiotic, optionally in combination with effective amount of a probiotic microbe or microbes.
Claims31
A method of treating lactose intolerance in a subject who has experienced one or more symptoms of lactose intolerance comprising:
- a) administering a hydrogen breath test (HBT) to said subject;
- b) diagnosing said subject as having lactose intolerance based upon a HBT result;
- and,
- c) administering from about 0.1 g to about 20 g of a pharmaceutical composition to said subject diagnosed as having lactose intolerance based upon said HBT result, wherein said pharmaceutical composition comprises at least 50% galactooligosaccharides (GOS) by weight.
A method of treating lactose intolerance in a subject who has experienced one or more symptoms of lactose intolerance, said method comprising:
- a) administering a diagnostic questionnaire to said subject, optionally in conjunction with a lactose or milk challenge;
- b) diagnosing said subject as having lactose intolerance based upon a diagnostic questionnaire result, wherein said diagnostic questionnaire result comprises subject-indicated severity scores for each of said one or more symptoms of lactose intolerance;
- and,
- c) administering from about 0.1 g to about 20 g of a pharmaceutical composition to said subject diagnosed as having lactose intolerance based upon said diagnostic questionnaire result, wherein said pharmaceutical composition comprises at least 50% GOS by weight.
A method of treating lactose intolerance in a subject who has experienced one or more symptoms of lactose intolerance comprising:
- a) diagnosing said subject as having lactose intolerance, wherein said diagnosing comprises a HBT test, a stool acidity test, a blood glucose test, a lactose challenge, a milk challenge, a diagnostic questionnaire, a self-reported history of having symptoms of lactose intolerance, or a combination thereof;
- and
- b) administering from about 0.1 g to about 20 g of a pharmaceutical composition comprising indigestible oligosaccharides to said subject diagnosed as having lactose intolerance, wherein said pharmaceutical composition comprising indigestible oligosaccharides selectively promotes growth of beneficial bacteria in the gastrointestinal tract of said subject, wherein said indigestible oligosaccharides comprise GOS and wherein at least 50% of said pharmaceutical composition by weight is GOS.
A method for treating lactose intolerance in a subject who has experienced one or more symptoms of lactose intolerance, said method comprising administering an effective amount of a pharmaceutical composition comprising at least 50% GOS by weight to said subject, wherein said effective amount of said pharmaceutical composition administered to said subject is based on said subject's weight.
A method for treating a subject who has experienced one or more symptoms comprising flatulence, heartburn, upset stomach, nausea, bloating, diarrhea, abdominal pain, cramping, or vomiting, the method comprising administering from about 0.1 g to about 20 g of a pharmaceutical composition comprising at least 50% GOS by weight and less than 20% digestible saccharides by weight to said subject, wherein said subject experiences a decrease in at least one of said one or more symptoms.
Dependencies are inferred from the claim text.