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US 8,785,149 B2Granted
In vitro cellular bioassay for neurotoxicity testing
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsLinda L. Restifo, Robert Kraft
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Abstract
The present invention provides neurotoxicity and developmental neurotoxicity screening methods employing primary cultured neurons from Drosophila.
Claims17
A method for determining the neurotoxicity of a compound comprising
- a) culturing Drosophila neurons in the presence of said compound;
- and
- b) assessing at least one characteristic of the neurons selected from the group of characteristics consisting of cell survival, neuronal body size, neuronal body shape, neurite outgrowth, neurite structure, neurite arbor shape, synapse number, and synapse function;
- wherein a modulation of at least one characteristic of the neuron compared to Drosophila neurons cultured in the absence of the compound indicates that said compound is neurotoxic.
1 more element
Dependencies are inferred from the claim text.