Method for diagnosing gram-negative infections
AssigneeIngen Biosciences
InventorsKarine Yvonne Gabrielle Mignon Godefroy, Hélène Nuyttens, Julie Roge, Damien Yann Marie-Joseph Thomas
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Abstract
The invention concerns an in vitro method for determining if an individual is infected by a gram-negative bacterium preferably on prosthesis comprising: (i) detection of antibodies directed against a polypeptide of sequence SEQ ID NO: 2 and antibodies directed against a polypeptide of sequence SEQ ID NO: 4, in a biological sample of the individual, and (ii) deduction therefrom that the individual is infected by a gram-negative bacterium. The invention further concerns the kit for diagnosing of such an infection.
Claims9
An in vitro method of determining if an individual is infected by a gram-negative bacterium, the method comprising:
- (a) detecting antibodies specific to the polypeptide of SEQ ID NO:
- 2 and antibodies specific to the polypeptide of SEQ ID NO:
- 4 in a biological sample of the individual, wherein the biological sample is selected from the group consisting of blood, serum, and plasma, and
- (b) deducing therefrom that the individual is infected by the gram-negative bacterium, wherein said infection is a biofilm-associated infection and the gram-negative bacterium is from a family selected from the group consisting of Enterobacteriaceae, Pasteurellaceae, and Pseudomonadaceae.
An in vitro method of determining if an individual is infected by a gram-negative bacterium, the method comprising:
- (a) contacting capture ligands specific to a polypeptide of the amino acid sequence SEQ ID NO:
- 2 and capture ligands specific to a polypeptide of the amino acid sequence SEQ ID NO:
- 4 with a biological sample of the individual, wherein the biological sample is selected from the group consisting of blood, serum, and plasma;
- (b) determining if said polypeptide of the amino acid sequence SEQ ID NO:
- 2 is bound to the capture ligands specific to the polypeptide of the amino acid sequence of SEQ ID NO:
- 2 and if said polypeptide of the amino acid sequence SEQ ID NO:
- 4 is bound to the capture ligands specific to the polypeptide of the amino acid sequence SEQ ID NO:
- 4;
- and
- (c) deducing therefrom that the individual is infected by the gram-negative bacterium, wherein said infection is a biofilm-associated infection and the gram-negative bacterium is from a family selected from the group consisting of Enterobacteriaceae, Pasteurellaceae, and Pseudomonadaceae.
Dependencies are inferred from the claim text.