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US 8,785,116 B2Granted
Methods for evaluating the suitability of an organ for transplant
AssigneeParagonix Technologies, Inc.
InventorsLisa Maria Anderson, Jared Alden Judson
Life of this patent
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Abstract
Methods of determining the health of an organ, such as a transplant organ, by measuring the ex-situ oxygen consumption rate of the organ. Systems for preserving and transporting organs while monitoring viability by measuring oxygen consumption rates.
Claims10
A method of evaluating the suitability of an organ for transplant comprising:
- perfusing the organ at hypothermic temperatures with an oxygenated solution using a mobile perfusion machine comprising a pneumatic system that oxygenates a preservation solution to create the oxygenated solution while varying the pressure of the oxygenated solution with the pneumatic system at least once per minute to create a differential perfusion pressure between about 5 mm Hg to about 30 mm Hg;
- measuring the oxygen consumption rate of the organ;
- and
- comparing the measured oxygen consumption rate to a functional oxygen consumption rate, wherein a measured oxygen consumption rate greater than or equal to a functional oxygen consumption rate is indicative of a suitable organ.
1 more element
Dependencies are inferred from the claim text.