US 8,784,911 B2Granted

Compositions for treatment and prevention of diabetic complications using Osteomeles schwerinae

AssigneeKorea Institute of Oriental Medicine

InventorsJin Sook Kim, Dae Sik Jang, Young Sook Kim, Yun Mi Lee, Joo-Hwan Kim, Eunjin Shon, Junghyun Kim, Chan-Sik Kim, Dong Ho Jung, Nan Hee Kim, Nam-Hee Yoo, Jun Lee

Life of this patent

Estimating the term…

patentgrep

Loading patent…

Abstract

The present invention relates to a treatment agent for diabetic complications, and a method for the treatment of diabetic complications using the same. The present invention confirmed that Osteomeles schwerinae extract and its fractions inhibited the generation of AGEs, the index for diabetic complications, inhibited the activation of aldose reductase, had anti-cataract activity, and had anti-oxidative activity. Thus, the present invention relates to a preventive and therapeutic agent for diabetic complications containing the said Osteomeles schwerinae extract and its fraction as an active ingredient.

Claims4

Dependent claims

A method for treatment of a diabetic complication comprising:

administering a pharmaceutically effective dose of a composition comprising an extract of Osteomeles schwerinae or a fraction thereof as an active ingredient to a subject having diabetes, wherein the diabetic complication is selected from the group consisting of diabetic nephropathy, diabetic retinopathy, and diabetic cataract;
wherein the extract is prepared by extracting Osteomeles schwerinae with ethanol or aqueous ethanol as an extracting solvent, and wherein the fraction is obtained by systematic sequential fractionation of the Osteomeles schwerinae extract using hexane, ethyl acetate, butanol and water in that order.

Dependencies are inferred from the claim text.

Facts

Application: 13/381,493Filed 5 Nov 2009
Published: US 2012/0100233 A126 Apr 2012
Granted: 22 Jul 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 36/73
Magnoliopsida: rosaceae , e.g. strawberry, chokeberry, blackberry, pear or firethorn
A23L 33/105
Using additives: plant extracts, their artificial duplicates or their derivatives
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 13/12
Drugs for disorders of the urinary system: of the kidneys

Family

US 2012/0100233 A1Pre-grant publication · published 26 Apr 2012
US 8,784,911 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

Building an agent or pulling many patents? Use the API or MCP server instead of scraping pages. Get an API key