Calcium carbonate granulation
AssigneeDelavau LLC
InventorsKevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
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Abstract
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
Claims16
A calcium carbonate granulation for pharmaceutical or nutraceutical tabletting comprising USP or food grade calcium carbonate powder having a median particle diameter from about 0.1 μm to about 20 μm;
- maltodextrin having a dextrose equivalent of 9 to 12;
- and a disintegrant, said granulation being highly compactable and free flowing, having sufficient cohesive properties for compression into tablets, and having a tap density between about 0.9 and about 2.0 g/cm3.
A calcium carbonate granulation for pharmaceutical or nutraceutical tabletting comprising:
- USP or food grade calcium carbonate powder having a median particle diameter from about 0.1 μm to about 20 μm;
- and maltodextrin having a dextrose equivalent (DE) of 9 to 12;
- said granulation being highly compactable and free flowing, having sufficient cohesive properties for compression into tablets, and having a tap density between about 0.9 and about 2.0 g/cm3.
Dependencies are inferred from the claim text.