Compositions and methods for cancer treatment
AssigneeSamuel Waxman Cancer Research Foundation
InventorsWilson H. Miller, Zuanel Diaz Heredia, Hyman M. Schipper, Koren K. Mann
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Abstract
The present invention relates to compositions comprising a vitamin E analog and an arsenic compound for treating hyperproliferative cells disorders such as cancer. The composition of the invention potentiates arsenic toxicity towards cancer cells and can also prevent arsenic-mediated toxicity of non-cancerous cells.
Claims14
A method for treating a mammal suffering from a neoplastic disease, the method comprising administering to said mammal a pharmaceutically effective amount of a composition comprising arsenic trioxide and 5 to 50 mg/kg body weight of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid wherein the 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid enhances inhibition by the arsenic trioxide of hyperproliferation of the neoplastic cells.
A method for inducing apoptosis in neoplastic cells, said method comprising contacting said neoplastic cells with an effective amount of a composition comprising arsenic trioxide and 5 to 50 mg/kg body weight of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox™) that is non-toxic to neoplastic cells, wherein the Trolox™ enhances induction by the arsenic trioxide of the apoptosis.
Dependencies are inferred from the claim text.