Polymer formulations for delivery of bioactive agents
AssigneeCarbylan Therapeutics, Inc.
InventorsGeorge Daniloff, David Gravett, Robert C. Spiro
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Abstract
Disclosed in the present application are compositions comprising a bioresorbable polymer matrix and a bio active agent, wherein the bioactive agent is dispersed within polymer matrix as a solid. Also provided herein are methods for preparing a bioactive agent formulation, wherein the agent is present in a solid form and, wherein the agent is occluded into a polymeric matrix by polymerization of polymer matrix precursors or by self assembly of the polymer.
Claims19
A hydrogel composition formed by combining an aqueous buffer, a thiol-functionalized hyaluronic acid and a crosslinking accelerant in the presence of a gel-persistence-enhancing compound selected from the group consisting of N-acetyl cysteine, glutathione, 2,3-dimercapto-1-propanesulfonic acid, 2,3-dimercapto-1-propanesulfonic acid sodium salt monohydrate, cysteine, dihydrolipoic acid, and pharmaceutically acceptable salts thereof, wherein the hydrogel comprises disulfide crosslinks.
Dependencies are inferred from the claim text.