Controlled release and taste masking oral pharmaceutical composition
AssigneeCosmo Technologies Limited
InventorsRoberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
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Abstract
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Claims9
A controlled release oral pharmaceutical composition consisting essentially of:
- (1) a tablet core consisting essentially of:
- a) budesonide in an amount effective to treat intestinal inflammatory disease;
- and
- b) a macroscopically homogeneous composition comprising at least one lipophilic excipient, at least one amphiphilic excipient, and at least one hydrogel-forming hydrophilic excipient other than a gum, wherein said budesonide is dispersed in said macroscopically homogeneous composition;
- and
- (2) a coating on said tablet core, said coating consisting essentially of a gastro-resistant film.
Dependencies are inferred from the claim text.