Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency

A multi-particulate digestive enzyme composition consisting essentially of coated digestive enzyme-containing beads, and uncoated digestive enzyme-containing beads, wherein:

• the enterically coated digestive enzyme-containing beads comprise a core and an enteric coating disposed over the core, wherein the core comprises a therapeutically effective amount of digestive enzymes, and the enteric coating comprises an enteric polymer;
• and
• the uncoated digestive enzyme-containing beads comprise a therapeutically effective amount of digestive enzymes, and is substantially free of an enteric polymer coating;
• wherein
• the digestive enzymes comprise lipase and protease, and the ratio of lipase and protease activities in the enterically coated digestive enzyme-containing beads to the lipase and protease activities in the uncoated digestive enzyme-containing beads ranges from about 5:95 to about 50:50.