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US 8,784,881 B2Granted
Liposomal curcumin for treatment of diseases
AssigneesBoard of Regents, The University of Texas System, Signpath Pharma, Inc.
InventorsRazelle Kurzrock, Lan Li, Kapil Mehta, Bharat Bhushan Aggarawal, Lawrence Helson
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Abstract
The present invention provides compositions and methods for the treatment of a human patient. The methods and compositions of the present invention include composition for the efficient loading of curcumin, comprising: an amount of a curcuminoid:liposome complex effective to load curcumin into the liposome, wherein the curcuminoids has between 2 to 9 weight percent of the total composition and the curcuminoids are natural or synthetic.
Claims3
A composition comprising:
- a curcumin:liposome complex, wherein the curcumin comprises between 2 to 9 weight percent of the curcumin:liposome complex, wherein the curcumin is at least one of natural or synthetic curcumin and wherein the curcumin:liposome complex has a ratio of curcumin to lipid (weight to weight) of 1:7.5 to 1:10, wherein the lipid combination is selected from:
- DMPC:Chol 9:1;
- DMPC:DMPG 9:1;
- DMPC:Chol:DMPG 8:1:1;
- DPPC:DMPG 9:1;
- DPPC:Chol:DMPG 8:1:1;
- DMPC:DSPE-PEG-2000 95:5;
- DMPC:Chol:DSPE-PEG-2000 90:10:05;
- DMPC/DMPG 7:3;
- DPPC/DMPG 7:3;
- DPPC/DMPG 9:1.
8 more elements
Dependencies are inferred from the claim text.