Controlled release delivery system for nasal applications and methods of treatment
AssigneeMattern Pharma AG
InventorClaudia Mattern
Life of this patent
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Abstract
This invention relates to a gel formulation for nasal administration of a controlled release formulation of hormones to the systemic circulation and/or to the brain. The special lipophilic or partly lipophilic system of the invention leads to higher bioavailability of the active ingredient caused by sustained serum levels in plasma but also leads to a more favorable serum level profile. The special lipophilic or partly lipophilic system also allows for the modulation of brain functioning. The invention also relates to the nasal administration of steroid hormones for treatment of female sexual dysfunction (FSD) or female arousal disorder.
Claims9
A formulation for nasal application comprising:
- a) testosterone, wherein said testosterone is present within the formulation in an amount of from about 0.2% to about 6% by weight of the formulation;
- b) at least one lipophilic or partly lipophilic carrier present in an amount of from about 60% to about 98% by weight of the formulation;
- c) at least one compound having surface tension decreasing activity present in an amount of from about 1% to about 20% by weight of the formulation;
- and
- d) at least one viscosity regulating agent present in an amount of from about 0.5% to about 10% by weight of the formulation.
Dependencies are inferred from the claim text.