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AssigneeHemoteq AG
InventorsRoland Horres, Marita Katharina Linssen, Michael Hoffmann, Erika Hoffmann, Donate DiBiase, Volker Faust
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The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
A metal stent, wherein the surface of the stent is coated directly and covalently with a hemocompatible layer, comprising at least one oligosaccharide and/or polysaccharide according to formulas (Ia) or (Ib):
A metallic stent, wherein the surface of the stent is coated with a hemocompatible layer comprising at least one oligosaccharide and/or polysaccharide according to formulas (Ia) or (Ib) and at least one interjacent biostable layer, wherein the interjacent biostable layer is covalently bonded to the stent and wherein the hemocompatible layer is covalently bonded to the interjacent biostable layer
Dependencies are inferred from the claim text.