Biobeneficial coating compositions and methods of making and using thereof
AssigneeAbbott Cardiovascular Systems Inc.
InventorStephen D. Pacetti
Life of this patent
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Abstract
A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.
Claims11
A method of treating a disorder in a subject by implanting in the subject an implantable device, wherein the implantable device comprising a coating which comprises a composition, wherein the composition comprises
- (1) a first block copolymer having the following structure:
- wherein m and n are positive integers, and
- (2) a second block copolymer comprising
- (i) a biobeneficial component selected from the group consisting of sodium hyaluronate, hyaluronic acid, heparin, and 4-amino-2,2,6,6-tetramethylpiperidine-1-oxide;
- and
- (ii) a component miscible with the first block copolymer selected from the group consisting of polystyrene-polyisobutylene-polystyrene block copolymer (SIS), polystyrene, and polyisobutylene.
A method of treating a disorder in a subject by implanting in the subject an implantable device, wherein the implantable device comprising a coating which comprises a composition, wherein the composition comprises
- (1) a first block copolymer having the following structure:
- wherein m and n are positive integers, and
- (2) a second block copolymer selected from the group consisting of SIS-hyaluronic acid (HA), polystyrene-HA, and polyisobutylene-HA.
Dependencies are inferred from the claim text.