Highly biocompatible dual thermogelling chitosan/glucosamine salt composition
OwnerAbdellatif Chenite, Amine Selmaniinventors
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Abstract
The present disclosure relates to a chitosan solution neutralized with amino-sugar carbonate buffering solution or amino-sugar phosphate buffering solution or phosphorylated aminosugar buffering solution. The resulting thermogelling chitosan composition is highly biocompatible, isotonic and has the ability to rapidly turn into gel upon heating to the body temperature. It provides a novel chitosan-based composition to suitable for drug delivery, cell delivery and repair or regeneration of tissues and organs as well as other clinical treatment.
Claims19
A method of treating, repairing, regenerating, replacing or substituting a tissue or organ within a mammalian or human body comprising the step of administering a thermogelling composition comprising:
- a) a chitosan solution;
- and
- b) a buffering solution consisting of an amino-sugar carbonate solution, an amino-sugar phosphate solution or a phosphorylated amino-sugar solution;
- wherein the composition, being liquid at a pH between 6.5 and 7.6, is biocompatible, isotonic and turns into gel when heated up to a temperature range between about 25° C. and about 60° C., and cooled down to a temperature range between about 8° C. and about 1° C.
Dependencies are inferred from the claim text.