US 8,784,845 B2 · Selective chemokine modulation

Abstract

The present invention teaches the use of a metal or an oxide of a metal having a capability of reducing the amount of the chemokine IP-IO in a sample and/or reducing the production of IP-IO in cells. The metal is a metal of group 4 or 5 in the periodic table of the elements and preferably titanium. These metals and metal oxides can selectively bind IP-IO to its surface to thereby scavenge IP-IO from the surrounding medium. In addition, a metal-cell contact induces a reduction in the production of IP-IO from IP-IO producing cells. The metals and metal oxides of the present invention can therefore be used for treating and/or preventing medical conditions characterized by adverse IP-IO expression, such as inflammatory reactions.

Claims19

Dependent claims

A method of reducing 10 kDa interferon-γ inducible protein, IP-10, in an extracted body fluid of a subject suffering from a disease characterized by adverse expression and/or release of IP-10, the method comprising:

extracting body fluid from the subject;
contacting said body fluid ex vivo with a metal selected from the group consisting of titanium, zirconium, hafnium, niobium and tantalum, or an oxide of said metal, wherein IP-10 in the body fluid binds to the metal or metal oxide;
removing the metal or oxide of the metal to which IP-10 is bound from the body fluid;
and
after said removal, returning said body fluid to said subject.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/441,000Filed 11 Sep 2007 · us provisional application

Priority

12 Sep 2006

Published

US 2010/0203089 A112 Aug 2010

Granted

22 Jul 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61M 1/38
Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood…
A61K 9/14
Medicinal preparations characterised by special physical form: particulate form, e.g. powders, Processes for size reducing of pure drugs or the…
A61K 33/24
Medicinal preparations containing inorganic active ingredients: heavy metals; Compounds thereof
A61M 1/3679
Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood…

Selective chemokine modulation

Life of this patent

Selective chemokine modulation

Life of this patent

Abstract

Claims19