Stabilizers for freeze-dried vaccines
AssigneeMerial Limited
InventorsDelphine Magali Belin-Poput, Noel Yves Henri Jean Genin
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Abstract
The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the present invention relates to stabilizers for freeze-dried live attenuated immunogenic and/or vaccine compositions, which may comprise, inter alia, canine paramyxovirus. The invention further relates to stabilized, freeze-dried live attenuated immunogenic and/or vaccine compositions of, for example, canine paramyxovirus, which may contain these stabilizers. Other aspects of the invention are described in or are obvious from the following disclosure, and are within the ambit of the invention.
Claims14
A stabilizer for a freeze-dried live attenuated canine distemper (CDV) and canine parainfluenza type 2 (cPi2) immunogenic composition comprising at least one reducing monosaccharide and at least one acid antioxidant compound, wherein the at least one acid antioxidant compound consists of aspartic acid;
- and wherein the at least one reducing monosaccharide consists of glucose, galactose, fructose, mannose, sorbose, or combinations thereof;
- wherein the at least one reducing monosaccharide is at a concentration from 20% to 50% w/w and the at least one acid antioxidant is at a concentration from 1.5% to 6% w/w;
- and wherein the stabilizer further consists of:
- (a) a bulking agent selected from dextran, maltodextrin, polyvinylpymolidone, hydroxyethyl starch, and combinations thereof, or
- (b) a sugar alcohol selected from sorbitol, mannitol, xylitol, maltitol and combinations thereof, or
- (c) a combination thereof;
- and
- wherein the stabilizer is capable of reducing the amount of CDV and cPi2 titer lost during the freezing process by at least 0.5 logs.
Dependencies are inferred from the claim text.