Attenuated live vaccines
AssigneeValneva Austria GmbH
InventorsFranz Xaver Heinz, Christian Mandl
Life of this patent
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Abstract
Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterized in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not affected by the deletion.
Claims13
An attenuated tick-borne encephalitis virus (TBE virus) live vaccine comprising a TBE virus mutant, wherein the TBE virus mutant has a deletion in the capsid protein of
- (a) 5 to 20 successive amino acids, or
- (b) more than 20 successive amino acids, wherein the capsid protein additionally comprises one or more further mutations by which the hydrophobicity of the capsid protein is increased, the further mutation being selected from
- i) point mutations by which the hydrophobicity of the capsid protein is increased, and/or
- ii) insertions of amino acid sections having predominantly hydrophobic properties, and
- wherein the deletion concerns regions of the internal hydrophobic domain of the capsid protein and wherein the carboxy-terminal hydrophobic region is not affected by the deletion.
A tick-borne encephalitis virus (TBE virus) vaccine, wherein the vaccine comprises a nucleic acid which codes for a deleted capsid protein that comprises a deletion of
- (a) 5 to 20 successive amino acids, or
- (b) more than 20 successive amino acids, wherein the capsid protein additionally comprises one or more further mutations by which the hydrophobicity of the capsid protein is increased, the further mutation being selected from
- i) point mutations by which the hydrophobicity of the capsid protein is increased, and/or
- ii) insertions of amino acid sections having predominantly hydrophobic properties, and
- wherein the deletion concerns regions of the internal hydrophobic domain of the capsid protein and wherein the carboxy-terminal hydrophobic region is not affected by the deletion.
Dependencies are inferred from the claim text.