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US 8,784,837 B2Granted
Vaccines comprising an immunostimulatory peptide and an immunostimulatory oligodeoxynucleic acid molecule
AssigneeValneva Austria GmbH
InventorsMichael Buschle, André Habel, Jörg Fritz, Karin Prinz, Karen Lingnau
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Abstract
The invention refers an improved vaccine against infections with pathogens, especially viral pathogens, comprising an antigen, a peptide of the formula R1—XZSZN—XZX—R2 and an immunostimulatory deoxynucleic acid containing deoxyinosine and/or deoxyuridine residues.
Claims18
A vaccine comprising:
- an HBV antigen;
- a peptide comprising the sequence KLKL5KLK (SEQ ID NO:
- 6);
- and
- a deoxyinosine-containing immunostimulatory oligodeoxynucleic acid molecule (I-ODN), wherein the I-ODN comprises oligo-d(IC)13 (SEQ ID NO:
- 21).
3 more elements
A immunogenic composition comprising:
- an HCV antigen,
- a peptide comprising the sequence KLKL5KLK (SEQ ID NO:
- 6), and
- a deoxyinosine-containing immunostimulatory oligodeoxynucleic acid molecule (I-ODN), wherein the I-ODN comprises oligo-d(IC)13 (SEQ ID NO:
- 21).
2 more elements
Dependencies are inferred from the claim text.