Microorganisms for therapy
AssigneeGenelux Corporation
InventorsAladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
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Abstract
Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
Claims19
A recombinant vaccinia virus, comprising a modified thymidine kinase (TK) gene and a modified hemagglutinin (HA) gene, and an insertion, deletion or mutation in the gene or locus designated F3, wherein:
- each of the TK, HA and F3 gene or locus is inactivated;
- and
- the F3 locus occurs on the HindIII-F fragment of the vaccinia virus between open reading frames F14L and F15L.
Dependencies are inferred from the claim text.