P. gingivalis antigenic composition
AssigneesCSL Limited, The University of Melbourne
InventorsEric Charles Reynolds, Nada Slakeski, Chao Guang Chen, Ian George Barr
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Abstract
The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
Claims7
An antigenic composition comprising at least one isolated and purified protein, wherein the isolated and purified protein consists of SEQ ID NO:
- 5 or a fragment thereof capable of raising an immune response against P. gingivalis, and wherein said protein is not complexed with other Arg-specific and Lys-specific P. gingivalis proteinase and adhesin proteins.
An antigenic composition comprising a chimeric protein, wherein the chimeric protein comprises a first and a second polypeptide, wherein the first polypeptide consists of SEQ ID NO:
- 5 or a fragment thereof capable of raising an immune response against P. gingivalis, and the second polypeptide comprises a P. gingivalis sequence.
Dependencies are inferred from the claim text.