Influenza hemagglutinin antibodies, compositions and related methods
AssigneeiBio, Inc.
InventorsVidadi Yusibov, Vadim Mett, Jessica Chichester, Lauren Goldschmidt
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Abstract
Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein.
Claims23
An isolated monoclonal antibody that binds hemagglutinin, wherein the antibody has the ability to inhibit hemagglutination, and wherein the antibody is selected from the group consisting of:
- an antibody comprising the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79, and the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78;
- and
- an antibody comprising the light chain variable region amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:81, and the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80.
An antibody that binds hemagglutinin, wherein the antibody has the ability to inhibit hemagglutination, and wherein the antibody is selected from the group consisting of:
- an antibody comprising the light chain amino acid sequence set forth in SEQ ID NO:79, and the heavy chain amino acid sequence set forth in SEQ ID NO:78;
- and
- an antibody comprising the light chain amino acid sequence set forth in SEQ ID NO:81, and the heavy chain amino acid sequence set forth in SEQ ID NO:80.
An antigen-binding fragment of an antibody that binds hemagglutinin and has the ability to inhibit hemagglutination, wherein the antigen-binding fragment comprises:
- the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79, and the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78;
- or
- the light chain variable region amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:81, and the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80;
- wherein the antigen-binding fragment is an scFv, Fv, Fab′, Fab, diabody, linear antibody, or F(ab′)2 antigen-binding fragment.
Dependencies are inferred from the claim text.