Antibodies which bind factor VIII

An isolated monoclonal antibody directed against factor VIII which is partially inhibiting factor VIII procoagulant activity, wherein said antibody is comprising:

• heavy chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs:
• 33, 34 and 35, respectively, and light chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs:
• 36, 37 and 38, respectively;
• or
• heavy chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs:
• 39, 40 and 41, respectively, and light chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs:
• 42, 43 and 44, respectively;
• or an antigen-binding fragment of any of said antibodies.