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US 8,784,814 B2Granted
Method for inhibiting binding to B-cell receptor
AssigneeGlaxo Group Limited
InventorsStuart Neville Farrow, Allard Kaptein, Jeremy David Alistair Kitson, Alison J. Winder
Life of this patent
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Abstract
The invention provides an isolated protein which is a member of the TNF ligand superfamily and comprises: i) a polypeptide having the amino acid sequence of figure (1); or ii) a variant of the polypeptide of i).
Claims7
A method of inhibiting the interaction in a mammal between a receptor on B-cells and a homotrimeric polypeptide comprising a first polypeptide having 99% sequence identity to SEQ ID NO:
- 1, said method comprising administering to said mammal an antibody or a fragment thereof that specifically binds a second polypeptide consisting of SEQ ID NO:2.
A method of inhibiting the binding of a receptor on B-cells with a homotrimeric polypeptide comprising a first polypeptide having 99% sequence identity to SEQ ID NO:
- 1, said method comprising contacting said homotrimeric polypeptide with an antibody or fragment thereof that specifically binds a second polypeptide consisting of SEQ ID NO:2.
Dependencies are inferred from the claim text.