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AssigneesCryopraxis Criobiologia Ltda., Universidade Federal de Sao Paulo - UNIFESP, University of South Florida
InventorsPaul R. Sanberg, Nelson Americo Hossne, Jr., Alison E. Willing, Adriana Invitti
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The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present invention provides methods of treating disorders by administering monocytes obtained from blood, including umbilical cord blood, peripheral blood, or bone marrow to an individual in need of treatment, wherein the drug is administered to the individual at a time point specifically determined to provide therapeutic efficacy. In one embodiment, the cells are for injection into ischemic myocardium for the treatment of angina.
A method of treatment of ischemia in a subject comprising injecting a therapeutic cell population into the ischemic tissue of the subject, wherein the therapeutic cell population comprises a mononuclear cell population enriched for monocyte lineage cells and wherein the monocyte lineage cells comprise promonocytes.
A method of improving perfusion in a subject comprising injecting a therapeutic cell population into a tissue of the subject in need of improved perfusion, wherein the therapeutic cell population comprises a mononuclear cell population enriched for monocyte lineage cells and wherein the monocyte lineage cells comprise promonocytes.
Dependencies are inferred from the claim text.