Bifidobacterium longum NCC2705 (CNCM I-2618) and immune disorders
AssigneeNestec S.A.
InventorsValerie Petit, Clara Garcia-Rodenas, Monique Julita, Guenolee Prioult, Annick Mercenier, Sophie Nutten
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Abstract
The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defenses. One embodiment of the present invention is the use of B. longum NCC2705 (deposit number CNCM 1-2618) for use in the treatment or prevention of disorders related to the immune system including infections.
Claims14
A method for the treatment of infections and disorders related to the immune system, the method comprising administering a composition comprising B. longum NCC 2705 (deposit number CNCM I-2618) to an individual suffering from a disorder linked to a reduced level of defensins, wherein the disorder is selected from the group consisting of cystic fibrosis, reactive airways disease, lung infections from tobacco smoking, asthma, pneumonia, rhinitis, otitis, sinusitis, tuberculosis, ulcerative colitis, intestinal immaturity, necrotising enterocolitis, antibiotic-associated diarrhea, bacterial vaginosis, HIV, Herpes simplex virus, urinary infection, atopic dermatitis, carcinoma, atopic eczema, burn injury, tonsillitis, gingivitis, dental caries, keratitis in eyes, and combinations thereof, and at least 95% of the B. longum NCC 2705 (deposit number CNCM I-2618) are rendered non-replicating by a heat treatment.
A method for boosting endogenous antimicrobial defenses, and/or the endogenous hBD2 and hBD1 expression, the method comprising administering a composition comprising B. longum NCC 2705 (deposit number CNCM I-2618) to an individual suffering from a disorder linked to a reduced level of defensins, wherein the disorder is selected from the group consisting of cystic fibrosis, reactive airways disease, lung infections from tobacco smoking, asthma, pneumonia, rhinitis, otitis, sinusitis, tuberculosis, ulcerative colitis, intestinal immaturity, necrotising enterocolitis, antibiotic-associated diarrhea, bacterial vaginosis, HIV, Herpes simplex virus, urinary infection, atopic dermatitis, carcinoma, atopic eczema, burn injury, tonsillitis, gingivitis, dental caries, keratitis in eyes, and combinations thereof, and at least 95% of the B. longum NCC 2705 (deposit number CNCM I-2618) are rendered non-replicating by a heat treatment.
Dependencies are inferred from the claim text.