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US 8,784,777 B2Granted
Flexibly labeling peptides
AssigneeCase Western Reserve University
InventorsMark D. Pagel, Byunghee Yoo
Life of this patent
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Abstract
A solid phase peptide synthesis method for synthesizing a peptidyl contrast agent is disclosed. In one example, the method includes synthesizing an amino-chelator loaded resin, coupling of the amino-chelator loaded resin to the C-terminus and/or backbone of a peptide, cleaving the amino-chelator-peptide from a resin, and chelating a lanthanide metal to the amino-chelator-peptide.
Claims8
A peptidyl imaging agent, comprising:
- a peptide, and
- a nitrogen-containing macrocyclic ring containing chelate coupled to an amidated C-terminus of the peptide,
- wherein the amide of the peptide is coupled within one carbon atom of the nitrogen in the macrocyclic ring containing of the chelate.
A peptidyl imaging agent, comprising:
- a peptide;
- and
- a nitrogen-containing macrocyclic ring chelate coupled within the backbone of the peptide,
- wherein an amide of the backbone of the peptide is coupled within one carbon atom of the nitrogen in the macrocyclic ring chelate.
1 more element
Dependencies are inferred from the claim text.