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US 8,784,774 B2Granted
Labeled molecular imaging agents and methods of use
AssigneeGeneral Electric Company
InventorsJack Mathew Webster, Bruce Fletcher Johnson, Brian Duh-Lan Lee, Chittari Pabba, Michael James Rishel
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Abstract
Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.
Claims7
A cystine/glutamate transporter imaging agent comprising a 18F labeled derivative of Formula I
- wherein:
- Formula I is a L-enantiomeric form;
- R2 is independently at each occurrence H and 18F wherein 18F is singularly occurring;
- and
- n is 5.
2 more elements
Dependencies are inferred from the claim text.