Formation of organic electro-grafted films on the surface of electrically conductive or semi-conductive surfaces

A process of coating a stent with an electro-grafted layer of poly-Hydroxyethylmethacrylate comprising the following steps:

• Cleaning with Detergent with Ultra-sonic 35 kHz power for 10 to 20 min;
• Rinsing with DI Water with Ultra-sonic 35 kHz power for 10 to 90 min;
• Drying;
• Contacting the stent with cathode of a power supply;
• Dipping in electrolytic solution comprising:
• hydroxyethylmethacrylate monomer, at a concentration of 1.5 to 2 mol/l;
• glycerol, at a concentration of 0.01 to 1 mol/l;
• dimethyl formamide as the solvent;
• 4-nitrophenyl diazonium tetrafluoroborate at a concentration of 5×10−4 to 10−1 mol/l;
• and
• sodium nitrate (NaNO3) at a concentration of 10−3 to 5×10−2 mol/l;
• with argon bubbling for 5 to 20 min;
• Providing in the electrolytic solution an anode connected to the power supply as a counterelectrode;
• Polarizing stent via a cyclic voltammetry protocol, scanning between 5 and 75 times from open circuit potential to −3 V/CE, where CE is the anode counterelectrode, at a scanning rate of 100 mV/s, with argon bubbling at 8 l/min;
• First rinsing in DMF with argon bubbling for 5 to 20 min;
• Second rinsing in DMF with argon bubbling for 5 to 20 min;
• Rinsing in DI Water for 5 to 20 min;
• and
• Drying in Vacuum oven at 40 C.°, 10 mbars for 30 to 180 min.

A process of coating a stent with an electro-grafted layer of poly-Butylmethacrylate comprising the following steps:

• Cleaning with Detergent with Ultra-sonic 35 kHz power for 10 to 20 min;
• Rinsing with DI Water with Ultra-sonic 35 kHz power for 10 to 90 min;
• Drying;
• Contacting the stent with cathode of a power supply;
• Dipping in electrolytic solution comprising:
• butylmethacrylate monomer, at a concentration of 1.5 to 2 mol/l;
• glycerol, at a concentration of 0.01 to 1 mol/l;
• dimethyl formamide as the solvent;
• 4-nitrophenyl diazonium tetrafluoroborate at a concentration of 5×10−4 to 10−1 mol/l;
• and
• sodium nitrate (NaNO3) at a concentration of 10−3 to 5×10−2 mol/l;
• with argon bubbling for 5 to 20 min;
• Providing in the electrolytic solution an anode connected to the power supply as a counterelectrode;
• Polarizing stent via a cyclic voltammetry protocol, scanning between 5 and 75 times from open circuit potential to −3.2 V/CE, where CE is the anode counterelectrode, at a scanning rate of 50 mV/s, with argon bubbling at 8 l/min;
• First rinsing in DMF with argon bubbling for 5 to 20 min;
• Second rinsing in DMF with argon bubbling for 5 to 20 min;
• Rinsing in DI Water for 5 to 20 min;
• and
• Drying in Vacuum oven at 40 C.°, 10 mbars for 30 to 180 min.