Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products

A method for imaging posterior structures of an eye using a scanning Fourier Domain optical coherence tomography (FDOCT) imaging system, the method comprising:

• positioning a rodent subject before the sample arm optics of the scanning FDOCT imaging system;
• adjusting a working distance between a distal most sample arm lens and a cornea of the rodent subject such that a conjugate of at least one scanning mirror is imaged within an eye of the rodent subject and posterior to the cornea, wherein a scanning beam pivots around a region interior to the eye of the rodent subject;
• imaging an optical radiation from an input optical fiber to a conjugate plane internal to the sample arm optics;
• and
• relaying an intermediate conjugate to a region posterior to a position of the conjugate of the at least one scanning minor and substantially within a region of the rodent subject retina, wherein the FDOCT imaging system uses an objective lens with a focal power selected in relation to a diameter of the rodent eye.

A computer program product for imaging posterior structures of an eye using a scanning Fourier Domain optical coherence tomography (FDOCT) system, the computer program product comprising:

• a non-transitory computer readable storage medium having computer readable program code embodied in the medium, the computer readable program code comprising:
• computer readable program code configured to image posterior structures of a rodent eye having a ball-lens ocular phenotype of a rodent subject using optics configured to image posterior to an ocular lens,
• wherein the optics image a conjugate of at least one scanning mirror to a region internal to an eye of the rodent subject and posterior to a cornea;
• and
• wherein the optics image optical radiation from an optical fiber input to a telecentric plane with a substantially flattened field curvature;
• and
• computer readable program code configured to image the conjugate to a region posterior to the conjugate of the at least one scanning mirror and substantially within a region of the rodent subject using an objective lens with a focal power selected in inverse proportion to a diameter of the rodent eye.