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US 8,783,089 B2Granted
Device and method for determining the properties of aerosol formulations
AssigneeBoehringer Ingelheim International GmbH
InventorsRegis Cartier, Marc Egen, Michael Krueger
Life of this patent
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Abstract
A device (100) for determining the solution rate and release kinetics of aerosol formulations comprises an inhaler (2) connected to a cascade impactor (3), wherein a membrane (6) is disposed on a filter plate of the cascade impactor (2), and an air-liquid model system with a device for collecting measured data.
Claims16
A test system for determining the solution rate and release kinetics of aerosol formulations, comprising:
- an inhaler (1), which is connected to a cascade impactor (3), while a hydrophilic membrane (6) is disposed on a filter plate of the cascade impactor (3) and is charged with particles,
- a Franz diffusion cell (13) into which the hydrophilic membrane (6) is disposed after being charged in the cascade impactor (3), wherein a first compartment (11) for receiving a liquid release medium is disposed underneath the hydrophilic membrane (6) and an air chamber is formed as a second compartment 12 above the hydrophilic membrane (6) within the Franz diffusion cell (13), and wherein the hydrophilic membrane (6) is in contact with a release medium, and
- a device for measurement data acquisition wherein medium from the first compartment is carried,
- wherein the hydrophilic membrane (6) comprises a material selected from among acrylic copolymer, polyethylene sulphone, polysulphone, cellulose, cellulose derivatives, cellulose esters and regenerated cellulose, and the hydrophilic membrane (6) has a maximum thickness of 100 μm.
1 more element
A process for determining the solution rate and release kinetics of aerosol formulations, comprising the steps of:
- releasing an aerosol that is to be measured from an inhaler (2) by means of a cascade impactor (3), wherein a membrane (6) is disposed on a filter plate in the cascade impactor (3), and
- measuring the particles immobilised on the membrane (6) by means of a Franz diffusion cell (13), wherein in the Franz diffusion cell (13) a first compartment 11 for receiving a liquid release medium is disposed underneath the membrane (6) and an air chamber is formed as a second compartment 12 above the membrane (6), and a device for measurement data acquisition,
- wherein the membrane (6) is made of a material selected from along acrylic copolymer, polyethylene sulphone, polysulphone, cellulose, cellulose derivatives, cellulose esters and regenerated cellulose, and the membrane having a maximum thickness of 100 μm.
Dependencies are inferred from the claim text.