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US 8,772,543 B2Granted
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
AssigneeMedarex, Inc.
InventorsHeng Cheng, Sanjeev Gangwar, Qiang Cong, Qian Zhang
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Abstract
Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
Claims15
A compound having a structure according to formula (VIII-b)
- wherein R9 and R10 are independently H or an amine protecting group and R11 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, cycloaliphatic, alkylcycloaliphatic, arylalkyl, or alkylaryl.
Dependencies are inferred from the claim text.