Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists

A pharmaceutical composition, comprising a compound represented by formula (I):

• wherein:
• R1 represents 1-azabicyclo[2.2.2]oct-3-yl;
• R2 represents hydrogen or C1-C6-alkyl;
• R3 represents hydrogen, halogen, amino, hydroxy or C1-C6-alkyl;
• R4 represents hydrogen or C1-C6-alkyl which is optionally substituted by a radical selected from the group of hydroxy, halogen, cyano, C1-C6-alkoxy, trifluoromethyl, or trifluoromethoxy,
• R5 represents hydrogen or C1-C6-alkyl;
• or R4 and R5 represent together with the nitrogen atom to which they are bonded are a 5- to 6-membered heterocycle which is optionally substituted by up to 2 substituents independently of one another selected from the group of C1-C6-alkyl, C1-C4-acyl, oxo, thioxo;
• R6 represents (i) hydrogen, (ii) C1-C6-alkyl, (iii) C3-C8-cycloalkyl, (iv) C6-C10-aryl, (v) 5- to 10-membered heteroaryl, or (vi) C6-C10-arylcarbonyl, where (ii) is optionally substituted by phenyl, C1-C6-alkoxycarbonyl or C1-C6-alkoxy, and (iv), (v) and (vi) are optionally substituted by up to 3 radicals selected independently of one another from the group of C1-C6-alkyl, C1-C6-hydroxyalkyl, 3- to 8-membered heterocyclyl, C6-C10-aryl, 5- to 10-membered heteroaryl, hydroxy, halogen, cyano, C1-C6-alkoxy, C1-C6-acyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6-alkylamino, or C1-C6-acylamino;
• or R5 and R6 represent together with the nitrogen atom to which they are bonded are a 3- to 10-membered heterocycle which is optionally substituted by C1-C6-alkyl or C1-C6-hydroxyalkyl;
• A represents oxygen or sulfur;
• X represents oxygen or sulfur;
• ring B represents benzo which is optionally substituted by radicals from the series halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6-alkyl and C1-C6-alkoxy;
• or a salt thereof;
• and
• a pharmaceutically acceptable carrier.