N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b

A compound of formula (I)

• the N-oxides, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein
• R1 is hydrogen, C1-4alkyl, halo, or polyhaloC1-4alkyl;
• R2 is hydrogen, C1-4alkyl, halo, or polyhaloC1-4alkyl;
• R3 is hydrogen or C1-4alkyl;
• R4 is hydrogen, C1-4alkyl, or halo;
• n is an integer 0, or 1;
• X1 is carbon and X2 is carbon;
• or X1 is nitrogen and X2 is carbon;
• or X1 is carbon and X2 is nitrogen;
• X3 is carbon or nitrogen;
• Y represents O, or NR6 wherein R6 is hydrogen or C1-4alkyl;
• R5 represents a radical of formula
• wherein
• m is an integer 0, 1, or 2;
• Z is O or NH;
• R7 is hydrogen,
• C1-6alkyl;
• C1-6alkyl substituted with hydroxy, amino, mono- or di(C1-4alkyl)amino, C1-4alkyloxycarbonyl, aminocarbonyl, aryl or heteroaryl;
• C1-4alkyl-O—C1-4alkyl;
• C1-4alkyl-S—C1-4alkyl;
• or
• aryl;
• R8 is hydrogen or C1-6alkyl;
• R9 is C1-4alkyl;
• or when Y represents NR6 the radicals R5 and R6 may be taken together with the nitrogen to which they are attached to form pyrrolidinyl substituted with C1-4alkyloxycarbonyl and optionally further substituted with hydroxy;
• or piperidinyl substituted with C1-4alkyloxycarbonyl;
• aryl is phenyl;
• phenyl substituted with one, two or three substituents each independently selected from C1-4alkyl, C1-4alkyloxy, halo, hydroxy, nitro, cyano, C1-4alkyloxycarbonyl, trifluoromethyl, or trifluoromethoxy;
• or benzo[1,3]dioxolyl;
• and
• heteroaryl is imidazolyl, thiazolyl, indolyl, or pyridinyl.