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AssigneeJiangsu Vcare PharmaTech Co., Ltd.
InventorsHongbin Sun, Jiaqi Shan, Boyu Zhang, Fang Yuan
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Optically active 2-hydroxytetrahydrothienopyridine derivatives represented by Formula I and pharmaceutically acceptable salts, preparation method and use in the manufacture of a medicament thereof are disclosed. The pharmacodynamic experiment results show that the present compounds of Formula I are useful for inhibiting platelet aggregation. The pharmacokinetic experiment results show that the present compound of Formula I can be converted in vivo into pharmacologically active metabolites and are therefore useful for inhibiting platelet aggregation. Therefore, the present compounds are useful for the manufacture of a medicament for preventing or treating thrombosis and embolism related diseases.
An optically active 2-hydroxytetrahydrothienopyridine derivative, wherein said derivative is (S)-methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)-acetate or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising (S)-methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)-acetate or a pharmaceutically acceptable salt thereof as an active ingredient, and a pharmaceutically acceptable carrier.
An optically active 2-hydroxytetrahydrothienopyridine derivative or a pharmaceutically acceptable salt thereof, wherein said derivative is (S)-methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)-acetate, wherein said pharmaceutically acceptable salt is a hydrochloric acid salt, a hydrobromic acid salt, a sulfuric acid salt, a citric acid salt, a tartaric acid salt, a phosphoric acid salt, a lactic acid salt, an acetic acid salt, a maleic acid salt, a fumaric acid salt, a malic acid salt, a mandelic acid salt, a methanesulfonic acid salt, a benzenesulfonic acid salt, a p-toluenesulfonic acid salt, a pamoic acid salt, an oxalic acid salt, or a succinic acid salt.
Dependencies are inferred from the claim text.