4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
AssigneeLexicon Pharmaceuticals, Inc.
InventorsArokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
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Abstract
Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
Claims9
A method of treating or managing irritable bowel syndrome, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, wherein R4 is lower alkyl.
A method of treating or managing Crohn's disease, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen or lower alkyl.
A method of treating or managing ulcerative colitis, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen or lower alkyl
Dependencies are inferred from the claim text.