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US 8,772,463 B2Granted
Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof
AssigneeSnu R&Db Foundation
InventorsSeung Bum Park, Hyang Yeon Lee, Jong Min Park
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Abstract
Disclosed are a novel fluorescent glucose analogue, a method for the synthesis thereof and the use thereof. The novel fluorescent glucose analogue is labeled with fluorescent dye by O-1-glycosylation and via various linkers. The fluorescent glucose analogue can be applied to molecular bioimaging and a method for screening curative or preventive drugs for glucose metabolism-related diseases.
Claims3
A fluorescent glucose analogue, represented by Formula 1 or Formula 2:
- wherein
- R1 is —(CH2)n-A-, wherein n is an integer of from 1 to 10, and A is piperazine;
- R2 is —(CH2)4-Cy3;
- and
- Y is O.
2 more elements
Dependencies are inferred from the claim text.