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US 8,772,457 B2Granted
BACE1 antibodies
AssigneeGenentech, Inc.
InventorsJasvinder Atwal, Yongmei Chen, Cecilia Pui Chi Chiu, Robert A. Lazarus, Weiru Wang, Ryan J. Watts, Yan Wu, Yingnan Zhang
Life of this patent
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Abstract
The invention provides antibodies to specific neural proteins and methods of using the same.
Claims28
An isolated antibody, or fragment thereof, that binds to β-site amyloid precursor protein cleaving enzyme 1 (BACE1) comprising
- (a) an HVR-H1 comprising the amino acid sequence GFTFX13GYX14IH (SEQ ID NO:26), wherein X13=S or L and X14=A or G,
- (b) an HVR-H2 comprising the amino acid sequence of GWISPAGGSTDYADSVKG (SEQ ID NO:24),
- (c) an HVR-H3 comprising the amino acid sequence of GPFSPWVMDY (SEQ ID NO:25),
- (d) an HVR-L1 comprising the amino acid sequence of RASQX1VX2X3X4X5A (SEQ ID NO:17), wherein X1=D or V;
- X2=S or A;
- X3=T or N;
- X4=S or A;
- X5=V or L,
- (e) an HVR-L2 comprising the amino acid sequence of X6ASFLYS (SEQ ID NO:18) wherein X6=S or L, and
- (f) an HVR-L3 comprising the amino acid sequence of QQX7X8X9X10X11X12T (SEQ ID NO:19), wherein X7=S, F, G, D or Y;
- X8=Y, P, S, or A;
- X9=T or N;
- X10=T, Y, D or S;
- X11=P or L;
- X12=P or T, and wherein the antibody reduces or inhibits the activity of the BACE1 polypeptide.
12 more elements
Dependencies are inferred from the claim text.