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US 8,772,342 B2Granted
Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
AssigneeGenfit
InventorsRaphael Darteil, Rémy Hanf, Dean Hum, Ingrid Dufour
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AssigneeGenfit
InventorsRaphael Darteil, Rémy Hanf, Dean Hum, Ingrid Dufour
Estimating the term…
The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as aminotransferases. The 1,3-diphenylprop-2-en-1-one derivatives of General Formula (I) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease.
A method for the treatment of a non-alcoholic fatty liver disease in a subject in need thereof, comprising administering to the subject a compound selected from 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one or a pharmaceutically acceptable salt or a stereoisomer thereof.
Dependencies are inferred from the claim text.