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US 8,772,340 B2Granted
Process for the preparation of fesoterodine or a salt thereof
AssigneeDipharma Francis S.R.L.
InventorsMarco Artico, Emanuele Attolino, Pietro Allegrini, Gabriele Razzetti
Life of this patent
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Abstract
A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having low content in impurities.
Claims10
A process for the preparation of Fesoterodine of formula (I), or a pharmaceutically acceptable salt thereof
- comprising the selective esterification of the phenolic hydroxyl of a compound of formula (II)
- wherein the selective esterification comprises the reaction of a compound of formula (II) with an acylating agent, in the presence of an alcoholic solvent and a base, wherein said alcoholic solvent is a C1-C2 alkanol, a mixture of C1-C2 alkanols or a mixture of a C1-C2 alkanol with an inert solvent.
A process for the preparation of a composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof,
- wherein said composition comprises at least one compound with a formula selected from the group consisting of formula (III), formula (IV) and formula (V)
- in an amount between about 0.0001% to about 0.1%, wherein said compound of formula (I) is prepared by a process comprising the selective esterification of the phenolic hydroxyl of a compound of formula (II)
- wherein the selective esterification comprises the reaction of a compound of formula (II) with an acylating agent, in the presence of an alcoholic solvent and a base, wherein said alcoholic solvent is a C1-C2 alkanol, a mixture of C1-C2 alkanols or a mixture of a C1-C2 alkanol with an inert solvent.
Dependencies are inferred from the claim text.