Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists

A compound of formula I

• wherein:
• R1 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 2-4C-alkenyl,2-4C-alkynyl, 1-4C-alkoxy, 1-4C-alkoxy-1-4C-alkyl, wholly or partially fluorine substituted 1-4C-alkyl, or wholly or partially fluorine substituted 1-4C-alkoxy,
• A is CR2R3, O, S, or NR2, wherein R2 is a group selected from hydrogen,1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, 1-4C-alkoxy, 1-4C-alkoxy-1-4C-alkyl, wholly or partially fluorine substituted 1-4C-alkyl, or wholly or partially fluorine substituted 1-4C-alkoxy, or R1 and R2 together represent a bond, or a 1-7C-alkanediyl group wherein one or two —CH2— groups are optionally replaced by —O—, and R3 is hydrogen or 1-4C-alkyl, and
• G is a bicyclic system G1or G2:
• wherein:
• R4 is a group optionally substituted by one to four R5 and/or R6,each independently selected from 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, aryl, heteroaryl, aryl-1-4C-alkyl, heteroaryl-1-4C-alkyl, heterocyclyl, and heterocyclyl-1-4C-alkyl, wherein:
• each R5 independently is hydrogen or a group optionally substituted by one to four R10 and/or R11 and/or R12, each independently selected from 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, aryl, heteroaryl, heterocyclyl, aryl-1-4C-alkyl, heteroaryl-1-4C-alkyl, and heterocyclyl-1-4C-alkyl, and
• each R6 independently is hydrogen or a group selected from:
• halogen,trifluoromethyl, cyano, oxo, —OR7, —N(R7)R8, —SR7, —C(O)OR7, —C(O)N(R7)R8, —S(O)2N(R7)R8, —C(O)R9, —S(O)2R9, —S(O)R9, —N(R81)C(O)OR7, —N(R81)C(O)N(R7)R8, —N(R81)S(O)2N(R7)R8, —N(R81)C(O)R9, —N(R81)S(O)2R9, and —N(R81)S(O)R9,
• wherein:
• each R7 independently is hydrogen or a group optionally substituted by one to four R10 and/or R11 and/or R12, each independently selected from 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, aryl, heteroaryl, heterocyclyl, aryl-1-4C-alkyl, heteroaryl-1-4C-alkyl, and heterocyclyl-1-4C-alkyl,
• each R8 independently is hydrogen or a group selected from 1-4C-alkyl and 3-7C-cycloalkyl, or R7 and R8 together represent a 1-9C-alkanediyl group wherein optionally one or two —CH2— groups may each be replaced by —O, —NR81, —S, —SO or —SO2—, wherein each R81 independently is hydrogen or 1-4C-alkyl,
• each R9 independently is a group optionally substituted by one to four R10 and/or R11 and/or R12, each independently selected from 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, aryl, heteroaryl, heterocyclyl, aryl-1-4C-alkyl, heteroaryl-1-4C-alkyl, and heterocyclyl-1-4C-alkyl,
• each R10 independently is a group selected from hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, aryl, heteroaryl, heterocyclyl, aryl-14C-alkyl, heteroaryl-1-4C-alkyl, and heterocyclyl-1-4C-alkyl,
• each R11 independently is hydrogen or a group selected from halogen, trifluoromethyl, cyano, oxo, —OR13, —N(R13)R14, and —SR13,
• each R12 independently is hydrogen or a group selected from —C(O)OR13, —C(O)N(R13)R14, —S(O)2N(R13)R14, —C(O)R15, —S(O)2R15—S(O)R15, —N(R141)C(O)OR13, —N(R141)C(O)N(R13)R14, —N(R141)S(O)2N(R13)R14, —N(R141)C(O)R15, —N(R141)S(O)2R15, and —N(R141)S(O)R15,
• each R13 independently is a group selected from hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, aryl, heteroaryl, heterocyclyl, aryl-1-4C-alkyl, heteroaryl-1-4C-alkyl, and heterocyclyl-1-4C-alkyl,
• each R14 independently is a group selected from hydrogen, 1-4C-alkyl, and 3-7C-cycloalkyl, or R13 and R14 together represent a 1-9C-alkanediyl group wherein optionally one or two —CH2— groups are each replaced by —O, —NR141, —S, —SO, or —SO2—, wherein each R141 independently is hydrogen or 1-4C-alkyl, and
• each R15 independently is a group selected from 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, aryl, heteroaryl, heterocyclyl, aryl-1-4C-alkyl, heteroaryl-1-4C-alkyl, and heterocyclyl-1-4C-alkyl,
• wherein:
• aryl, on its own or as part of another group, is a carbocyclic aromatic monocyclic ring system containing 6 carbon atoms, which is optionally annelated to a second 5- or 6-membered carbocyclic aromatic, saturated or unsaturated ring system,
• heteroaryl, on its own or as part of another group, is a 5-to 12-membered, aromatic, monocyclic or condensed-polycyclic ring system containing 1 to 4 heteroatoms independently selected from N, O, and S(O)r with r=0, 1, or 2, wherein at least one of the heteroatoms is part of the aromatic ring, and
• heterocyclyl, on its own or as part of another group, a 3- to 12-membered, saturated, unsaturated or aromatic, monocyclic or condensed, bridged or spiro-polycyclic ring system containing 1 to 4 heteroatoms independently selected from N, O, and S(O)r with r=0, 1, or 2, wherein none of the heteroatoms is part of the aromatic ring,
• or a tautomer, enantiomer, or a salt thereof.